Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 11/20 | 0.41 |
| ▸ | SPR | P35270 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | FPR2 | P25090 | 4/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007988 | 0.85 | TRPV4 (0.58) | TRPV4ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL20003550 | 0.85 | TRPV4 (0.58) | TRPV4ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL20003548 | 0.76 | TRPV4 (0.52) | TRPV4ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL20003707 | 0.76 | TRPV4 (0.52) | TRPV4ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL23176162 | 0.75 | PKM (0.54) | TRPV4 | |
| SCHEMBL20007244 | 0.74 | TRPV4 (0.46) | TRPV4L3MBTL1 | |
| SCHEMBL20003562 | 0.73 | TRPV4 (0.51) | TRPV4SPRALDH1A1SMN1; SMN2 | |
| SCHEMBL20007296 | 0.73 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL23613832 | 0.73 | TRPV4 (0.57) | TRPV4 | |
| SCHEMBL23613871 | 0.72 | TRPV4 (0.60) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |