Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007287 | 0.86 | TRPV4 (0.55) | TRPV4 | |
| SCHEMBL20003506 | 0.76 | CYP19A1 (0.60) | CYP3A4TRPV4CYP19A1 | |
| SCHEMBL12778088 | 0.76 | HTR2A (0.49) | HTR2AHTR2CTDO2TRPV4ALOX5AP | |
| SCHEMBL30266475 | 0.72 | TRPV4 (0.48) | CYP3A4CYP2C19HTR2AHTR2CTRPV4 | |
| SCHEMBL20007707 | 0.72 | TRPV4 (0.70) | CYP3A4TRPV4 | |
| SCHEMBL20007281 | 0.71 | TRPV4 (0.52) | CYP3A4CYP2C19TRPV4ALOX5APFEN1 | |
| SCHEMBL20003532 | 0.71 | ACLY (0.53) | CYP3A4CYP2C19TRPV4 | |
| SCHEMBL23613927 | 0.71 | CYP3A4 (0.39) | CYP3A4CYP2C19HTR2AHTR2CTRPV4 | |
| SCHEMBL12778131 | 0.70 | HTR2A (0.44) | HTR2AHTR2CTRPV4 | |
| SCHEMBL22771131 | 0.69 | TRPV4 (0.42) | TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |