Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 12/20 | 0.55 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | FABP1 | P07148 | 1/20 | 0.39 |
| ▸ | RBP1 | P09455 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20007697 | 0.81 | TRPV4 (0.52) | TRPV4RBP1KDM4EALDH1A1NR3C1 | |
| SCHEMBL23613943 | 0.78 | TRPV4 (0.44) | TRPV4FABP1POLBKDM4EALDH1A1 | |
| SCHEMBL20007281 | 0.74 | TRPV4 (0.52) | TRPV4FABP1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL20007271 | 0.74 | TRPV4 (0.43) | TRPV4TRPM8RBP1 | |
| SCHEMBL20007310 | 0.74 | TRPV4 (0.49) | TRPV4TRPM8 | |
| SCHEMBL23613847 | 0.74 | TRPV4 (0.57) | TRPV4TRPM8KDM4E | |
| SCHEMBL23614016 | 0.73 | TRPV4 (0.55) | TRPV4TRPM8 | |
| SCHEMBL23176371 | 0.73 | TRPV4 (0.55) | TRPV4TRPM8 | |
| SCHEMBL20003515 | 0.73 | TRPV4 (0.52) | TRPV4TRPM8RBP1 | |
| SCHEMBL20003513 | 0.73 | TRPV4 (0.61) | TRPV4TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055524-A1 | TRPV4 ANTAGONISTS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2018-03-29 | — | — | WO | disclosed |