Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.40 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.39 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.39 |
| ▸ | AHCY | P23526 | 2/20 | 0.39 |
| ▸ | DNPH1 | O43598 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23080228 | 0.84 | NAE1 (0.37) | NAE1UBA3AHCYALDH1A1ADORA2A | |
| SCHEMBL20007970 | 0.83 | DNPH1 (0.38) | P2RX7FGFR1FGFR4NAE1UBA3 | |
| SCHEMBL21283410 | 0.83 | TMIGD3 (0.52) | ADORA2AADORA1PDE4APDE4BPDE4C | |
| SCHEMBL23080250 | 0.81 | NAE1 (0.38) | NAE1UBA3AHCYALDH1A1ADORA2A | |
| SCHEMBL23080289 | 0.77 | NAE1 (0.41) | NAE1UBA3ALDH1A1ADORA2AADORA1 | |
| SCHEMBL18631311 | 0.77 | ADORA3 (0.41) | NAE1UBA3ADORA2AADORA1PDE4A | |
| SCHEMBL20008118 | 0.76 | AHCY (0.33) | NAE1UBA3AHCYALDH1A1ADORA2A | |
| SCHEMBL18630514 | 0.76 | NAE1 (0.58) | NAE1UBA3 | |
| SCHEMBL23080267 | 0.76 | NAE1 (0.39) | NAE1UBA3 | |
| SCHEMBL20008056 | 0.75 | NAE1 (0.48) | NAE1UBA3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | ECE1, RNASE1, RCE1 | P2RX7 3017/4885FGFR1 1797/4885FGFR4 3509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.