Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | BRS3 | P32247 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28819054 | 0.78 | NFE2L2 (0.44) | FEN1LNPEPRAB9A | |
| SCHEMBL20979570 | 0.74 | ABL1 (0.35) | ABL1FEN1RAF1 | |
| Formic Acid SCHEMBL28013976 | 0.73 | NFE2L2 (0.38) | FEN1HTR6LNPEP | |
| SCHEMBL20009436 | 0.73 | MAPK14 (0.41) | ABL1RAF1 | |
| SCHEMBL21312554 | 0.73 | NFE2L2 (0.38) | FEN1LNPEPMAP4K4 | |
| SCHEMBL21240974 | 0.72 | MAP4K4 (0.42) | HTR6MEN1RAB9AKMT2ANPSR1 | |
| SCHEMBL27641375 | 0.71 | SYK (0.35) | SYKKCNJ6KCNJ3 | |
| SCHEMBL14107706 | 0.66 | FEN1 (0.45) | ABL1FEN1IRAK4RAF1MAP4K4 | |
| SCHEMBL507751 | 0.66 | CXCR4 (0.40) | FEN1 | |
| SCHEMBL10229782 | 0.66 | CYP1A2 (0.51) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |