Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28819054 | 0.95 | NFE2L2 (0.44) | NFE2L2TRPA1FEN1HTR3AHRH4 | |
| SCHEMBL21312118 | 0.82 | HRH3 (0.44) | MAP4K4HRH4ADRA2C | |
| SCHEMBL24742808 | 0.78 | TRPA1 (0.54) | TRPA1FEN1HTR3AHRH4 | |
| SCHEMBL15984521 | 0.75 | TRPA1 (0.36) | TRPA1HTR3AHRH4CTSDBACE1 | |
| SCHEMBL24593793 | 0.74 | KDM1A (0.44) | TRPA1HRH4 | |
| SCHEMBL507751 | 0.74 | CXCR4 (0.40) | TRPA1FEN1HTR3AHRH4CYP11B2 | |
| SCHEMBL20008219 | 0.73 | ABL1 (0.43) | FEN1MAP4K4LNPEP | |
| SCHEMBL21240974 | 0.73 | MAP4K4 (0.42) | TRPA1MAP4K4HTR3AHRH4CYP11B2 | |
| SCHEMBL29055311 | 0.73 | LNPEP (0.35) | NFE2L2MAP4K4MCHR1LNPEP | |
| SCHEMBL18924441 | 0.70 | CXCR4 (0.37) | NFE2L2TRPA1HTR3AHRH4LNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019165192-A1 | 5-HETEROARYL SUBSTITUTED INDAZOLE-3-CARBOXAMIDES AND PREPARATION AND USE THEREOF | SAMUMED, LLC (US) | 2019-08-29 | — | — | WO | disclosed |