Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.34 |
| ▸ | LATS1 | O95835 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008248 | 0.81 | KMO (0.37) | SMARCA2SMARCA4PBRM1NR1I2CNR2 | |
| SCHEMBL20008486 | 0.79 | CNR2 (0.45) | CNR2KMOSMN1; SMN2OPRK1RAF1 | |
| SCHEMBL20010168 | 0.78 | BRAF (0.51) | RAF1BRAF | |
| SCHEMBL24394501 | 0.71 | PLAU (0.40) | SMARCA2SMARCA4PBRM1NR1I2RAF1 | |
| SCHEMBL29829632 | 0.71 | PLAU (0.40) | SMARCA2SMARCA4PBRM1NR1I2RAF1 | |
| SCHEMBL20008328 | 0.71 | CNR2 (0.48) | CNR2SMN1; SMN2RAF1BRAF | |
| SCHEMBL20008238 | 0.71 | KMO (0.37) | KMORAF1BRAF | |
| SCHEMBL29829402 | 0.69 | MAPT (0.54) | SMARCA2SMARCA4PBRM1NR1I2SMN1; SMN2 | |
| SCHEMBL20008469 | 0.68 | CNR2 (0.38) | CNR2RAF1BRAFPDE10A | |
| SCHEMBL29829241 | 0.68 | NT5E (0.52) | SMARCA2SMARCA4PBRM1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |