Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.35 |
| ▸ | CDC42BPB | Q9Y5S2 | 4/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.33 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008359 | 0.84 | CNR2 (0.42) | CNR2ALDH1A1HTTPOLBSMN1; SMN2 | |
| SCHEMBL20008469 | 0.83 | CNR2 (0.38) | CNR2PDE10AROCK2ROCK1CDC42BPB | |
| SCHEMBL20008475 | 0.83 | RAF1 (0.39) | ROCK2ROCK1CDC42BPBRAF1BRAF | |
| SCHEMBL20008296 | 0.79 | SMARCA2 (0.40) | CNR2PDE10AOPRK1RAF1BRAF | |
| SCHEMBL20008328 | 0.79 | CNR2 (0.48) | CNR2ALDH1A1GAARAF1BRAF | |
| SCHEMBL20009443 | 0.75 | RAF1 (0.37) | CNR2ROCK2ROCK1CDC42BPBRAF1 | |
| SCHEMBL20008381 | 0.75 | RAF1 (0.45) | RAF1BRAFGRIN1GRIN2B | |
| SCHEMBL20008472 | 0.74 | RAF1 (0.38) | VRK1RAF1BRAF | |
| SCHEMBL20008341 | 0.73 | RAF1 (0.38) | ROCK2ROCK1CDC42BPBRAF1BRAF | |
| SCHEMBL20008216 | 0.73 | RAF1 (0.47) | ROCK2ROCK1CDC42BPBRAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |