Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | RAF1 | P04049 | 14/20 | 0.34 |
| ▸ | BRAF | P15056 | 14/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008486 | 0.83 | CNR2 (0.45) | CNR2RAF1BRAFROCK2ROCK1 | |
| SCHEMBL20008259 | 0.71 | RAF1 (0.38) | RAF1BRAF | |
| SCHEMBL20008326 | 0.70 | RAF1 (0.39) | RAF1BRAF | |
| SCHEMBL20008328 | 0.70 | CNR2 (0.48) | CNR2RAF1BRAF | |
| SCHEMBL20008289 | 0.70 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20008359 | 0.69 | CNR2 (0.42) | CNR2 | |
| SCHEMBL20008475 | 0.69 | RAF1 (0.39) | RAF1BRAFROCK2ROCK1CDC42BPB | |
| SCHEMBL20008296 | 0.68 | SMARCA2 (0.40) | CNR2RAF1BRAFPDE10A | |
| SCHEMBL20008768 | 0.68 | RAF1 (0.37) | RAF1BRAF | |
| SCHEMBL20008149 | 0.67 | RAF1 (0.40) | RAF1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |