Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 18/20 | 0.40 |
| ▸ | BRAF | P15056 | 18/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009716 | 0.75 | RAF1 (0.41) | RAF1BRAF | |
| SCHEMBL20008233 | 0.72 | RAB9A (0.39) | — | |
| SCHEMBL20008376 | 0.67 | RAF1 (0.42) | RAF1BRAF | |
| SCHEMBL29878210 | 0.66 | RAF1 (0.58) | RAF1BRAF | |
| SCHEMBL20008426 | 0.64 | RAF1 (0.40) | RAF1BRAF | |
| SCHEMBL20008427 | 0.64 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL22561964 | 0.62 | RAF1 (0.50) | RAF1BRAF | |
| SCHEMBL29877986 | 0.62 | RAF1 (0.54) | RAF1BRAF | |
| SCHEMBL26003063 | 0.62 | BRAF (0.48) | RAF1BRAF | |
| SCHEMBL20008784 | 0.61 | BTK (0.34) | RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |