Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19529299 | 0.72 | SMN1; SMN2 (0.41) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL20008336 | 0.72 | RAF1 (0.40) | — | |
| SCHEMBL20009063 | 0.72 | NPC1 (0.39) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL20008363 | 0.70 | MAPT (0.37) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL26242740 | 0.70 | HPGD (0.54) | RAB9ANPC1HTTSMN1; SMN2GAA | |
| SCHEMBL20008308 | 0.69 | NPC1 (0.36) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL20008464 | 0.68 | NPC1 (0.30) | RAB9ANPC1KMT2A | |
| SCHEMBL20008487 | 0.68 | NPC1 (0.36) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL20008254 | 0.68 | NPC1 (0.34) | RAB9ANPC1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL20009541 | 0.65 | TP53 (0.32) | RAB9ANPC1SMN1; SMN2KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |