Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 17/20 | 0.33 |
| ▸ | BRAF | P15056 | 17/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008405 | 0.68 | OPRK1 (0.32) | HPGD | |
| SCHEMBL20009148 | 0.66 | RAF1 (0.51) | RAF1BRAF | |
| SCHEMBL22562129 | 0.61 | RAF1 (0.52) | RAF1BRAF | |
| SCHEMBL20008497 | 0.59 | BRAF (0.45) | RAF1BRAF | |
| SCHEMBL15962693 | 0.57 | RAB9A (0.54) | HPGD | |
| SCHEMBL20008179 | 0.56 | MAPT (0.31) | MAPT | |
| SCHEMBL20008594 | 0.56 | RAF1 (0.47) | RAF1BRAF | |
| SCHEMBL20009513 | 0.56 | — | — | |
| SCHEMBL20008137 | 0.56 | PIK3C3 (0.31) | — | |
| SCHEMBL18484474 | 0.55 | SMYD3 (0.51) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |