Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | DRD4 | P21917 | 2/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19529299 | 0.69 | SMN1; SMN2 (0.41) | RAB9ASMN1; SMN2CYP2D6NPC1 | |
| SCHEMBL20008464 | 0.66 | NPC1 (0.30) | RAB9AKMT2ANPC1 | |
| SCHEMBL20008233 | 0.65 | RAB9A (0.39) | TP53RAB9AKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL25464953 | 0.64 | CYP2D6 (0.40) | TP53MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL20008581 | 0.63 | TP53 (0.39) | TP53DRD2DRD4DRD3RAB9A | |
| SCHEMBL20008429 | 0.61 | TP53 (0.40) | TP53RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12846473 | 0.61 | HPGD (0.58) | RAB9AMEN1KMT2ATSHRNPC1 | |
| SCHEMBL20008272 | 0.61 | TP53 (0.40) | TP53RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15306495 | 0.60 | HPGD (0.57) | TP53RAB9AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL20008223 | 0.58 | TP53 (0.39) | TP53RAB9AMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |