Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008272 | 0.74 | TP53 (0.40) | TP53NPC1RAB9AMAPTLMNA | |
| SCHEMBL20009427 | 0.73 | CYP3A4 (0.30) | CYP2D6MEN1KMT2A | |
| SCHEMBL20008581 | 0.71 | TP53 (0.39) | TP53NPC1RAB9AMEN1KMT2A | |
| SCHEMBL20008487 | 0.64 | NPC1 (0.36) | TP53NPC1RAB9AMAPTLMNA | |
| SCHEMBL12846473 | 0.64 | HPGD (0.58) | NPC1RAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL20009603 | 0.64 | MEN1 (0.36) | NPC1RAB9AMAPTLMNACYP2D6 | |
| SCHEMBL15306495 | 0.63 | HPGD (0.57) | TP53NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL20008164 | 0.63 | MAPT (0.32) | NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL20008150 | 0.63 | RAB9A (0.41) | NPC1RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL20008573 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |