Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 2/20 | 0.80 |
| ▸ | APP | P05067 | 2/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acridine Orange SCHEMBL297155 | 0.89 | TERT (1.00) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL29361720 | 0.89 | TERT (1.00) | TERTAPPALDH1A1KDM4EAPAF1 | |
| SCHEMBL9276222 | 0.88 | APAF1 (0.64) | TERTAPPALDH1A1KDM4EGAA | |
| Acridine Orange SCHEMBL30153753 | 0.87 | TERT (0.95) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL20816123 | 0.87 | TERT (0.95) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL29597528 | 0.87 | TERT (0.95) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL22071 | 0.87 | TERT (0.95) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL8408019 | 0.85 | APP (0.91) | TERTAPPALDH1A1KDM4EAPAF1 | |
| Acridine Orange SCHEMBL31143792 | 0.85 | TERT (0.91) | TERTAPPALDH1A1APAF1EGFR | |
| Acridine Orange SCHEMBL5859399 | 0.85 | TERT (0.91) | TERTAPPALDH1A1KDM4EAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086713-A1 | CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | UNIVERSITY OF WASHINGTON | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086713-A1 | CGAS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) | STING1, IRF3, CGAS | TERT 3483/4885APP 3191/4885ALDH1A1 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.