Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 8/20 | 0.51 |
| ▸ | F2 | P00734 | 6/20 | 0.51 |
| ▸ | KLK1 | P06870 | 6/20 | 0.51 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.51 |
| ▸ | HPN | P05981 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.51 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.51 |
| ▸ | TMPRSS15 | P98073 | 11/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | C1R | P00736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008665 | 0.90 | PRSS1 (0.47) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008685 | 0.90 | TMPRSS15 (0.41) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008680 | 0.83 | F2 (0.51) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008686 | 0.82 | TMPRSS15 (0.47) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20009151 | 0.80 | PRSS1 (0.58) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008679 | 0.80 | PRSS1 (0.55) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008677 | 0.80 | KMT2A (0.39) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008662 | 0.77 | KLK1 (0.55) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL21920058 | 0.74 | PRSS1 (0.74) | PRSS1F2KLK1TMPRSS2HPN | |
| SCHEMBL20008692 | 0.74 | F10 (0.39) | PRSS1F2KLK1TMPRSS2HPN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | OPRM1, OPRK1, OPRD1 | PRSS1 952/4885F2 3807/4885KLK1 3383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.