Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RHOA | P61586 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18984964 | 0.82 | CYP3A4 (0.59) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL11043471 | 0.79 | CYP3A4 (0.56) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL225275 | 0.78 | ALDH1A1 (0.54) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL4786272 | 0.77 | ALDH1A1 (0.54) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL17147852 | 0.77 | ALDH1A1 (0.58) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL1992502 | 0.76 | CYP3A4 (0.51) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL8041829 | 0.75 | CYP3A4 (0.73) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL5278956 | 0.74 | ALDH1A1 (0.60) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| Bicarbonate SCHEMBL20838538 | 0.74 | CYP3A4 (0.92) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 | |
| SCHEMBL759012 | 0.73 | ALDH1A1 (1.00) | ALDH1A1HSD17B10TSHRCYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | disclosed |
| US-8236840-B2 | Thiopene containing analogues of fluconazole as antifungal agents and process for their preparation | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-07 | — | — | US | disclosed |
| EP-2346861-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | Council of Scientific and Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | COUNCIL OF SCIENCE & INDUSTRIAL RESEARCH (IN) | 2011-06-16 | — | — | US | disclosed |
| WO-2010046912-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-04-29 | — | — | WO | disclosed |
| EP-0234557-B1 | 3-(1H-Tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-11-28 | — | — | EP | disclosed |
| US-4761474-A | 3-(1H-tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-02 | — | — | US | disclosed |
| EP-0234557-A1 | 3-(1H-Tetrazol-5-yl)thieno[2,3-d]pyrimidin-4(3H)-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-09-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | CYP51A1, ERG28, TPMT | ALDH1A1 2097/4885HSD17B10 1689/4885TSHR 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.