Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6643211 | 0.82 | ALDH1A1 (0.53) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL18984964 | 0.77 | CYP3A4 (0.59) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL2000878 | 0.76 | ALDH1A1 (0.58) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL11043471 | 0.75 | CYP3A4 (0.56) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL7824635 | 0.73 | PTPN2 (0.58) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL546304 | 0.72 | PTK2 (0.59) | ALDH1A1HSD17B10KMT2AMEN1MAPT | |
| SCHEMBL10376521 | 0.70 | SNCA (0.52) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL29362146 | 0.69 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL27474785 | 0.69 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A | |
| SCHEMBL16371573 | 0.69 | CYP3A4 (1.00) | CYP3A4ALDH1A1TSHRHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | claimed |
| EP-2346861-B1 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL SCIENT IND RES (IN) | 2013-01-23 | — | — | EP | disclosed |
| US-8236840-B2 | Thiopene containing analogues of fluconazole as antifungal agents and process for their preparation | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2012-08-07 | — | — | US | disclosed |
| EP-2346861-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | Council of Scientific and Industrial Research (IN) | 2011-07-27 | — | — | EP | disclosed |
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | COUNCIL OF SCIENCE & INDUSTRIAL RESEARCH (IN) | 2011-06-16 | — | — | US | disclosed |
| WO-2010046912-A2 | THIOPHENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144171-A1 | THIOPENE CONTAINING ANALOGUES OF FLUCONAZOLE AS ANTIFUNGAL AGENTS AND PROCESS FOR THEIR PREPARATION | CYP51A1, ERG28, TPMT | CYP3A4 10/4885ALDH1A1 2097/4885TSHR 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.