Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.35 |
| ▸ | BRAF | P15056 | 4/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 14/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009328 | 0.78 | — | — | |
| SCHEMBL20008331 | 0.74 | RAF1 (0.43) | RAF1BRAFGRIN2BGRIN1 | |
| SCHEMBL20008281 | 0.64 | GRIN2B (0.52) | GRIN2BGRIN1ALDH1A1L3MBTL1 | |
| SCHEMBL20010072 | 0.64 | RAF1 (0.48) | RAF1BRAF | |
| SCHEMBL20008381 | 0.63 | RAF1 (0.45) | RAF1BRAFGRIN2BGRIN1 | |
| SCHEMBL23654808 | 0.61 | RAF1 (0.41) | RAF1BRAFGRIN2BGRIN1 | |
| SCHEMBL20049822 | 0.61 | ALDH1A1 (0.51) | GRIN2BGRIN1ALDH1A1L3MBTL1 | |
| SCHEMBL20008148 | 0.60 | CRHR1 (0.32) | — | |
| SCHEMBL20008353 | 0.59 | CRHR1 (0.32) | — | |
| SCHEMBL20171236 | 0.59 | ALDH1A1 (0.50) | GRIN2BGRIN1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |