Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 12/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 11/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20049822 | 0.84 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1PARP1GAAATM | |
| SCHEMBL17946110 | 0.81 | EGLN1 (0.50) | GRIN2BSMN1; SMN2 | |
| SCHEMBL20008281 | 0.80 | GRIN2B (0.52) | ALDH1A1L3MBTL1PARP1GAAATM | |
| SCHEMBL11483670 | 0.79 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1PARP1GAAATM | |
| SCHEMBL1420984 | 0.77 | PIN1 (0.56) | ALDH1A1PARP1GRIN2BGRIN1SMN1; SMN2 | |
| SCHEMBL10647000 | 0.77 | KDM4E (0.51) | ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8274248 | 0.76 | GRIN1 (0.56) | ALDH1A1L3MBTL1PARP1GAAATM | |
| SCHEMBL22239384 | 0.76 | ALOX5 (0.56) | GRIN2BGRIN1SMN1; SMN2 | |
| SCHEMBL28307674 | 0.76 | SCN2A (0.48) | ALDH1A1L3MBTL1PARP1GAAATM | |
| SCHEMBL27295912 | 0.75 | AGBL2 (0.46) | ALDH1A1L3MBTL1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357911-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics Inc. (US) | 2018-08-08 | — | — | EP | disclosed |
| EP-3323807-A1 | PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE | Akebia Therapeutics, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |