Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 8/20 | 0.33 |
| ▸ | BRAF | P15056 | 8/20 | 0.33 |
| ▸ | DDX3X | O00571 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23654079 | 0.68 | IDO1 (0.33) | BRAF | |
| SCHEMBL20008327 | 0.67 | RAF1 (0.59) | RAF1BRAF | |
| SCHEMBL20009436 | 0.65 | MAPK14 (0.41) | RAF1ABL1MAPK14 | |
| SCHEMBL20008141 | 0.64 | BRAF (0.31) | BRAF | |
| SCHEMBL20008778 | 0.63 | RAF1 (0.37) | RAF1BRAFMAPK14 | |
| SCHEMBL20008772 | 0.63 | BRAF (0.31) | BRAF | |
| SCHEMBL23654969 | 0.62 | BRAF (0.33) | BRAFABL1MAPK14LCKKDR | |
| SCHEMBL20009415 | 0.62 | RAF1 (0.37) | RAF1BRAFMAPK14 | |
| SCHEMBL20010055 | 0.61 | CRHR1 (0.32) | — | |
| SCHEMBL20008143 | 0.61 | BRAF (0.38) | BRAFABL1MAPK14LCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |