Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009422 | 0.85 | MEN1 (0.33) | TSHR | |
| SCHEMBL20008548 | 0.83 | TP53 (0.31) | — | |
| SCHEMBL20008186 | 0.82 | — | — | |
| SCHEMBL20008523 | 0.71 | LMNA (0.34) | ALDH1A1 | |
| SCHEMBL26084626 | 0.71 | CASP1 (0.37) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL20009423 | 0.71 | MEN1 (0.36) | TSHR | |
| SCHEMBL20008773 | 0.70 | CASP1 (0.42) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL20009099 | 0.69 | — | — | |
| SCHEMBL19061357 | 0.69 | CASP1 (0.41) | CASP1TSHRALDH1A1CYP3A4PDE10A | |
| SCHEMBL20009414 | 0.69 | MEN1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |