Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008429 | 0.73 | TP53 (0.40) | CYP2D6MEN1KMT2A | |
| SCHEMBL20009603 | 0.63 | MEN1 (0.36) | CYP2D6MEN1KMT2AUTS2R | |
| SCHEMBL16956618 | 0.59 | MEN1 (0.42) | CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL22856978 | 0.59 | MEN1 (0.39) | CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL19230297 | 0.58 | LMNA (0.37) | CYP2C9MEN1KMT2A | |
| SCHEMBL26081524 | 0.58 | SMN1; SMN2 (0.34) | MEN1KMT2A | |
| SCHEMBL25464953 | 0.58 | CYP2D6 (0.40) | CYP3A4CYP2D6CYP2C9MEN1KMT2A | |
| SCHEMBL20157023 | 0.57 | TP53 (0.35) | — | |
| SCHEMBL18380832 | 0.57 | GAA (0.46) | CYP3A4CYP2D6MEN1KMT2A | |
| SCHEMBL23373396 | 0.57 | TP53 (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |