Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901854 | 0.85 | CYP1A2 (0.38) | HPRT1ALDH1A1TSHRACHEKDM4E | |
| SCHEMBL6562728 | 0.77 | HPRT1 (0.46) | SLC6A4SLC6A3HPRT1HTR1BHTR2B | |
| SCHEMBL30366540 | 0.77 | HPRT1 (0.46) | SLC6A4SLC6A3HPRT1HTR1BHTR2B | |
| SCHEMBL1557325 | 0.74 | CYP1A2 (0.62) | ALDH1A1TSHRACHEKDM4EL3MBTL1 | |
| SCHEMBL13357232 | 0.70 | — | — | |
| SCHEMBL13755279 | 0.70 | CNR2 (0.35) | ALDH1A1HTT | |
| SCHEMBL16917822 | 0.69 | HTR1B (0.42) | SLC6A4SLC6A3HPRT1HTR1BHTR2B | |
| SCHEMBL423873 | 0.69 | CYP1A2 (0.68) | SLC6A4SLC6A3HPRT1HTR1BHTR2B | |
| SCHEMBL18805057 | 0.69 | CYP1A2 (0.68) | SLC6A4SLC6A3HPRT1HTR1BHTR2B | |
| SCHEMBL29618976 | 0.65 | CES2 (0.43) | SLC6A4HPRT1ALDH1A1TSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018054365-A1 | NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2018-03-29 | — | — | WO | disclosed |