Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | GLA | P06280 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20011217 | 0.88 | ALDH1A1 (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL7990085 | 0.82 | RAB9A (0.77) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22607227 | 0.79 | ALDH1A1 (0.76) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL19995264 | 0.78 | TSHR (0.62) | ALDH1A1RAB9ASMN1; SMN2GAAHPGD | |
| SCHEMBL17068797 | 0.71 | TP53 (0.68) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL19995293 | 0.70 | KDM4E (1.00) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL16157180 | 0.70 | SMN1; SMN2 (0.76) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL9058883 | 0.70 | HTT (0.79) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL21143456 | 0.68 | KMT2A (0.73) | ALDH1A1SMN1; SMN2HPGDMAPTHSD17B10 | |
| SCHEMBL26051623 | 0.68 | HPGD (0.67) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515435-B1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | UNIV BAR ILAN (IL) | 2026-02-25 | — | — | EP | claimed |
| US-12150940-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | BAR ILAN UNIVERSITY (IL) | 2024-11-26 | — | — | US | claimed |
| US-11123339-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | BAR ILAN UNIVERSITY (IL) | 2021-09-21 | — | — | US | claimed |
| EP-3515435-B1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | UNIV BAR ILAN (IL) | 2026-02-25 | — | — | EP | disclosed |
| US-12150940-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | BAR ILAN UNIVERSITY (IL) | 2024-11-26 | — | — | US | disclosed |
| US-20210361642-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2021-11-25 | — | — | US | disclosed |
| US-20210361642-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2021-11-25 | — | — | US | disclosed |
| US-11123339-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | BAR ILAN UNIVERSITY (IL) | 2021-09-21 | — | — | US | disclosed |
| US-11123339-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | BAR ILAN UNIVERSITY (IL) | 2021-09-21 | — | — | US | disclosed |
| US-20190216794-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2019-07-18 | — | — | US | disclosed |
| US-20190216794-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2019-07-18 | — | — | US | disclosed |
| WO-2018055627-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12150940-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | XIAP, BRWD1, ZAP70 | ALDH1A1 4585/4885NPC1 2333/4885RAB9A 1657/4885 |
| US-20210361642-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | XIAP, BRWD1, ZAP70 | ALDH1A1 4585/4885NPC1 2333/4885RAB9A 1657/4885 |
| US-11123339-B2 | WASp-protecting small molecules, compositions, methods and uses thereof in the treatment of innate and acquired immune-related disorders or conditions | XIAP, BRWD1, ZAP70 | ALDH1A1 4585/4885NPC1 2333/4885RAB9A 1657/4885 |
| US-20190216794-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | XIAP, BRWD1, ZAP70 | ALDH1A1 4585/4885NPC1 2333/4885RAB9A 1657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.