Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 14/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | TYK2 | P29597 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012904 | 0.87 | CDK4 (0.54) | ALKJAK2CDK2CDK4CCND1 | |
| SCHEMBL20012903 | 0.84 | SYK (0.53) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL20012936 | 0.81 | WEE1 (0.47) | SYKJAK2JAK1JAK3CDK4 | |
| SCHEMBL20012909 | 0.79 | PDGFRB (0.50) | ALKJAK2CDK2IGF1RCDK4 | |
| SCHEMBL20012906 | 0.77 | CDK4 (0.46) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL3934496 | 0.76 | CYP17A1 (0.67) | — | |
| SCHEMBL20012916 | 0.76 | JAK2 (0.60) | ALKJAK2CDK2CDK4AURKA | |
| SCHEMBL20012911 | 0.75 | EGFR (0.57) | ALKJAK2CDK4AURKACDK1 | |
| SCHEMBL20012912 | 0.75 | ALK (0.62) | ALKJAK2JAK3CDK2IGF1R | |
| SCHEMBL20012950 | 0.75 | AURKA (0.54) | ALKSYKJAK2CDK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |