Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.46 |
| ▸ | JAK3 | P52333 | 6/20 | 0.45 |
| ▸ | JAK2 | O60674 | 5/20 | 0.45 |
| ▸ | JAK1 | P23458 | 5/20 | 0.45 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CD38 | P28907 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012903 | 0.90 | SYK (0.53) | CDK4AURKAJAK3JAK2JAK1 | |
| SCHEMBL20012909 | 0.90 | PDGFRB (0.50) | CDK4AURKAFGFR1JAK2FGFR4 | |
| SCHEMBL20012991 | 0.89 | FGFR1 (0.53) | CDK4AURKAFGFR1JAK3JAK2 | |
| SCHEMBL20012920 | 0.87 | TTK (0.57) | FGFR1PTK2IGF1R | |
| SCHEMBL20012936 | 0.83 | WEE1 (0.47) | CDK4JAK3JAK2JAK1FGFR4 | |
| SCHEMBL20012904 | 0.81 | CDK4 (0.54) | CDK4AURKAFGFR1JAK2FGFR4 | |
| SCHEMBL20012902 | 0.78 | INSR (0.60) | IGF1R | |
| SCHEMBL20012919 | 0.77 | ALK (0.58) | CDK4AURKAJAK3JAK2JAK1 | |
| SCHEMBL20012945 | 0.77 | INSR (0.62) | AURKAFGFR1JAK2FGFR4KDR | |
| SCHEMBL20012932 | 0.75 | FGFR3 (0.58) | FGFR1FGFR4KDRFGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |