Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | WEE1 | P30291 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.47 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012932 | 0.92 | FGFR3 (0.58) | FGFR3KCNH2 | |
| SCHEMBL20012947 | 0.87 | WEE1 (0.52) | TNK2FGFR3FLT3WEE1TNIK | |
| SCHEMBL20012904 | 0.83 | CDK4 (0.54) | TNK2PDGFRBPDGFRAFGFR3BRD4 | |
| SCHEMBL15244156 | 0.79 | FGFR3 (0.65) | TNK2PDGFRBPDGFRAFGFR3FLT3 | |
| SCHEMBL20012945 | 0.76 | INSR (0.62) | PDGFRBPDGFRAFGFR3FLT3JAK2 | |
| SCHEMBL29458704 | 0.75 | TNK2 (0.61) | TNK2PDGFRBPDGFRAFGFR3FLT3 | |
| SCHEMBL29727293 | 0.75 | FGFR3 (0.65) | PDGFRBPDGFRAFGFR3FLT3WEE1 | |
| SCHEMBL29576376 | 0.75 | WEE1 (0.60) | TNK2PDGFRBPDGFRAFGFR3FLT3 | |
| SCHEMBL20012909 | 0.74 | PDGFRB (0.50) | PDGFRBPDGFRAFGFR3WEE1PAK1 | |
| SCHEMBL20012902 | 0.73 | INSR (0.60) | TNK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |