Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 10/20 | 0.62 |
| ▸ | IGF1R | P08069 | 10/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 10/20 | 0.62 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.58 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.56 |
| ▸ | PLK1 | P53350 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20012920 | 0.91 | TTK (0.57) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL20012909 | 0.87 | PDGFRB (0.50) | INSRIGF1RALKPDGFRBPDGFRA | |
| SCHEMBL20012932 | 0.86 | FGFR3 (0.58) | EGFRFGFR1FGFR2FGFR4FGFR3 | |
| SCHEMBL20012902 | 0.85 | INSR (0.60) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL15244473 | 0.81 | INSR (0.68) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL18912630 | 0.78 | INSR (0.68) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL30003588 | 0.78 | INSR (0.65) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL26087590 | 0.77 | ALK (0.73) | INSRIGF1RALKLRRK2MAPK7 | |
| SCHEMBL20012904 | 0.77 | CDK4 (0.54) | INSRALKPDGFRBPDGFRAEGFR | |
| SCHEMBL20012906 | 0.77 | CDK4 (0.46) | IGF1RPTK2AURKAJAK2FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018056621-A1 | NOVEL IMIDAZOLYL PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CANCER | 재단법인 대구경북첨단의료산업진흥재단 | 2018-03-29 | — | — | WO | disclosed |