Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 9/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CBLB | Q13191 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25997633 | 0.87 | TYK2 (0.48) | TYK2GSK3BCBLB | |
| SCHEMBL84076 | 0.84 | L3MBTL1 (0.52) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| SCHEMBL15358566 | 0.81 | AAK1 (0.49) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| SCHEMBL21078952 | 0.81 | AAK1 (0.49) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL15350524 | 0.80 | AAK1 (0.48) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| SCHEMBL6951836 | 0.80 | MAPKAPK2 (0.49) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| SCHEMBL13165570 | 0.75 | TYK2 (0.66) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 | |
| SCHEMBL19127763 | 0.74 | L3MBTL1 (0.52) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| Ammonia Solution, Strong SCHEMBL28494689 | 0.72 | L3MBTL1 (0.53) | L3MBTL1PIK3C3JAK2JAK1TYK2 | |
| SCHEMBL30518614 | 0.72 | AAK1 (0.49) | L3MBTL1MAPKAPK2PIK3C3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932320-B2 | Quinoline-based kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-04-03 | — | — | US | disclosed |