Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 10/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15358566 | 1.00 | AAK1 (0.49) | AAK1L3MBTL1PIK3C3MAPKAPK2CYP3A4 | |
| Hydrochloric Acid SCHEMBL15350524 | 0.98 | AAK1 (0.48) | AAK1L3MBTL1PIK3C3MAPKAPK2CYP3A4 | |
| SCHEMBL84076 | 0.87 | L3MBTL1 (0.52) | AAK1L3MBTL1PIK3C3MAPKAPK2JAK2 | |
| SCHEMBL21079055 | 0.86 | TYK2 (0.50) | TYK2 | |
| SCHEMBL15358570 | 0.86 | TYK2 (0.50) | TYK2 | |
| Hydrochloric Acid SCHEMBL15350070 | 0.84 | TYK2 (0.49) | TYK2 | |
| SCHEMBL15358568 | 0.83 | JAK2 (0.48) | AAK1JAK2JAK1TYK2 | |
| SCHEMBL15358582 | 0.83 | LMNA (0.45) | AAK1L3MBTL1CYP3A4 | |
| SCHEMBL6951836 | 0.83 | MAPKAPK2 (0.49) | AAK1L3MBTL1PIK3C3MAPKAPK2JAK2 | |
| SCHEMBL15358583 | 0.82 | EGFR (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841421-B1 | AMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2019-06-05 | — | — | EP | disclosed |