Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.45 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84076 | 0.85 | L3MBTL1 (0.52) | MAPKAPK2L3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL15358566 | 0.83 | AAK1 (0.49) | MAPKAPK2L3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL21078952 | 0.83 | AAK1 (0.49) | MAPKAPK2L3MBTL1PIK3C3JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL15350524 | 0.81 | AAK1 (0.48) | MAPKAPK2L3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL20016547 | 0.80 | L3MBTL1 (0.46) | MAPKAPK2L3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL7962904 | 0.76 | PTGS1 (0.50) | — | |
| SCHEMBL29626722 | 0.74 | NR3C2 (0.44) | MAPKAPK2RIOK2TYK2POLBNR3C2 | |
| SCHEMBL21200001 | 0.74 | NR3C2 (0.44) | MAPKAPK2RIOK2TYK2POLBNR3C2 | |
| SCHEMBL24031007 | 0.73 | PTGS2 (0.46) | — | |
| SCHEMBL2183698 | 0.73 | AKR1C3 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674623-B1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |