Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.36 |
| ▸ | BCR | P11274 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15030737 | 0.88 | GAA (0.40) | SLC6A7LSSPLA2G2AHPGDMEN1 | |
| SCHEMBL408373 | 0.79 | RBP4 (0.36) | SLC6A7LSSPLA2G2APOLBHPGD | |
| SCHEMBL8947386 | 0.78 | HPGD (0.57) | HPGDMEN1KMT2ANPC1TSHR | |
| SCHEMBL19542472 | 0.74 | FASN (0.63) | — | |
| SCHEMBL15154808 | 0.72 | GAA (0.56) | SLC6A7HPGDKMT2ANPC1ALDH1A1 | |
| SCHEMBL2834492 | 0.70 | KDM4E (0.56) | HPGDMEN1KMT2ANPC1TSHR | |
| SCHEMBL21485419 | 0.69 | CHRNB2 (0.43) | SLC6A7HPGD | |
| SCHEMBL16598889 | 0.69 | GPR183 (0.62) | — | |
| SCHEMBL16598891 | 0.69 | GPR183 (0.62) | — | |
| SCHEMBL7432657 | 0.68 | XDH (0.51) | POLBHPGDKMT2AABL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788487-B1 | OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA | SAREPTA THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |