Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRK6 | P43250 | 1/20 | 0.48 |
| ▸ | RHEB | Q15382 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512905 | 0.88 | KDM4E (0.48) | KDM4EALDH1A1LMNANPC1PKM | |
| SCHEMBL18719838 | 0.86 | LMNA (0.66) | KDM4EALDH1A1LMNANPC1PKM | |
| SCHEMBL1505455 | 0.82 | GABRG2 (0.50) | ALDH1A1NPC1HPGDRAB9ACA1 | |
| SCHEMBL7432657 | 0.81 | XDH (0.51) | LMNANPC1PKMHPGDRAB9A | |
| SCHEMBL17303478 | 0.81 | LMNA (0.37) | KDM4EALDH1A1LMNANPC1PKM | |
| SCHEMBL3658350 | 0.81 | MAPT (0.45) | KDM4EALDH1A1LMNANPC1HPGD | |
| SCHEMBL2819906 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL30807521 | 0.79 | HPGDS (0.55) | KDM4EALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL27141845 | 0.79 | HPGDS (0.55) | KDM4EALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL733150 | 0.79 | GABRG2 (0.44) | KDM4EALDH1A1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3762367-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI Industries Ltd. (IN) | 2021-01-13 | — | — | EP | disclosed |
| US-20210002232-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2021-01-07 | — | — | US | disclosed |
| US-20210002232-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2021-01-07 | — | — | US | disclosed |
| WO-2019171234-A9 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2020-01-09 | — | — | WO | disclosed |
| WO-2019171234-A9 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2020-01-09 | — | — | WO | disclosed |
| WO-2019171234-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2019-09-12 | — | — | WO | disclosed |
| WO-2019171234-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | PI INDUSTRIES LTD. (IN) | 2019-09-12 | — | — | WO | disclosed |
| EP-2492262-B1 | FUSED HETEROCYCLIC COMPOUND AND THROMBOPOIETIN RECEPTOR ACTIVATOR | NISSAN CHEMICAL IND LTD (JP) | 2016-04-20 | — | — | EP | disclosed |
| CN-103641820-B | Tetrazolium imines coumarins copper ion fluorescence probe and preparation method thereof | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-01-20 | — | — | CN | disclosed |
| US-8889732-B2 | Fused heterocyclic compounds and thrombopoietin receptor activators | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2014-11-18 | — | — | US | disclosed |
| US-20120209005-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2012-08-16 | — | — | US | disclosed |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2010-07-01 | — | — | US | disclosed |
| US-7696231-B2 | Oxindole hydrazide modulators of protein tyrosine phosphatases (PTPs) | LABORATOIRES SERONO SA (CH) | 2010-04-13 | — | — | US | disclosed |
| US-7229987-B2 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | ELI LILLY AND COMPANY (US) | 2007-06-12 | — | — | US | disclosed |
| US-20050272718-A1 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | AMMENN ET AL, JOCHEN | 2005-12-08 | — | — | US | disclosed |
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. | 2005-02-24 | — | — | US | disclosed |
| EP-1505968-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2005-02-16 | — | — | EP | disclosed |
| EP-1439834-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003097047-A1 | MULTICYCLIC COMPOUNDS FOR USE AS MELANIN CONCENTRATING HORMONE ANTAGONISTS IN THE TREATMENT OF OBESITY AND DIABETES | ELI LILLY AND COMPANY (US) | 2003-11-27 | — | — | WO | disclosed |
| WO-2003037328-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120209005-A1 | FUSED HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS | MPL, TEK, THPO | KDM4E 4664/4885ALDH1A1 2398/4885LMNA 1285/4885 |
| US-20210002232-A1 | HETEROCYCLIC COMPOUNDS AS FUNGICIDES | CYP1A2, CYP1B1, CYP1A1 | KDM4E 1965/4885ALDH1A1 120/4885LMNA 2446/4885 |
| US-20050043388-A1 | Oxindole hydrazide modulators of protein tyrosine phosphatases (ptps) | PTPRO, PTPRE, PTPRZ1 | KDM4E 2215/4885ALDH1A1 774/4885LMNA 4869/4885 |
| US-20050272718-A1 | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes | MC1R, MC4R, MC5R | KDM4E 2751/4885ALDH1A1 716/4885LMNA 3898/4885 |
| US-20100168101-A1 | OXINDOLE HYDRAZIDE MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | PTPRO, PTPRE, PTPRZ1 | KDM4E 2146/4885ALDH1A1 798/4885LMNA 4869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.