Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12656338 | 0.79 | LMNA (0.41) | LMNAAKR1B1ALDH1A1RAB9AMAPT | |
| SCHEMBL12626404 | 0.74 | LMNA (0.43) | LMNAALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL12655651 | 0.73 | LMNA (0.36) | LMNAAKR1B1ALDH1A1RAB9AMAPT | |
| SCHEMBL12656063 | 0.73 | LMNA (0.43) | LMNAALDH1A1RAB9AMAPTNPC1 | |
| SCHEMBL12623896 | 0.73 | ALDH1A1 (0.40) | LMNAAKR1B1ALDH1A1RAB9AMAPT | |
| SCHEMBL12656286 | 0.72 | ALDH1A1 (0.40) | LMNAAKR1B1ALDH1A1RAB9AMAPT | |
| SCHEMBL21202625 | 0.70 | GLA (0.38) | LMNAALDH1A1MAPTSMN1; SMN2USP5 | |
| SCHEMBL12656195 | 0.70 | RAB9A (0.34) | LMNAAKR1B1ALDH1A1RAB9AMAPT | |
| SCHEMBL12626407 | 0.70 | GPR119 (0.40) | — | |
| SCHEMBL13363631 | 0.69 | GPR119 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2918587-B1 | Filamin A binding compounds and their use as anti-inflammatory and analgesic agents | PAIN THERAPEUTICS INC (US) | 2018-04-04 | — | — | EP | disclosed |