Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021173 | 0.87 | PLA2G2A (0.40) | KDM4EPLA2G2ADHODHESR1ESR2 | |
| SCHEMBL3323941 | 0.86 | KDM4E (0.51) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL20021110 | 0.84 | KDM4E (0.45) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL3297610 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL3303954 | 0.82 | KDM4E (0.53) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL20021122 | 0.81 | KDM4E (0.52) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL20021074 | 0.79 | KDM4E (0.44) | KDM4ESMN1; SMN2DHODHPTGDR2MEN1 | |
| SCHEMBL3321643 | 0.79 | KDM4E (0.48) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL3314187 | 0.79 | KDM4E (0.50) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 | |
| SCHEMBL3331488 | 0.79 | KDM4E (0.51) | KDM4ESMN1; SMN2LMNADHODHPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |