Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707384 | 0.82 | SLC18A3 (0.38) | OPRM1CCR5 | |
| SCHEMBL3839394 | 0.81 | TP53 (0.37) | ALDH1A1PKMMAPTOPRM1LMNA | |
| SCHEMBL3888064 | 0.81 | GNAI3 (0.38) | POLBOPRM1CCR5 | |
| SCHEMBL17095965 | 0.81 | OPRM1 (0.39) | OPRM1CCR5 | |
| SCHEMBL1305394 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL17440239 | 0.78 | HSD11B1 (0.48) | JAK2JAK1 | |
| SCHEMBL17440237 | 0.78 | HSD11B1 (0.48) | JAK2JAK1 | |
| SCHEMBL1305914 | 0.76 | KDM4E (0.36) | ALDH1A1PKMPOLBMAPTLMNA | |
| SCHEMBL28851436 | 0.76 | UBE2M (0.38) | ALDH1A1PKMSMN1; SMN2 | |
| SCHEMBL17095677 | 0.75 | OPRM1 (0.40) | OPRM1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960380-B2 | Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |