Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 8/20 | 0.50 |
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | CPA1 | P15085 | 4/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22178675 | 1.00 | ALDH1A1 (0.51) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 | |
| SCHEMBL22427640 | 0.86 | L3MBTL1 (0.50) | MMEACEACE2NPC1RAB9A | |
| SCHEMBL24200453 | 0.85 | TSHR (0.50) | ALDH1A1CYP2C9CYP2C19MMEACE | |
| SCHEMBL683352 | 0.84 | NPSR1 (0.55) | MMEACEACE2NPC1RAB9A | |
| SCHEMBL1627622 | 0.84 | CTSS (0.58) | ALDH1A1NPC1RAB9A | |
| SCHEMBL684246 | 0.84 | NPSR1 (0.55) | MMEACEACE2NPC1RAB9A | |
| SCHEMBL12864507 | 0.84 | MME (0.69) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL8510053 | 0.84 | MME (0.69) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL8510050 | 0.84 | MME (0.69) | MMEACECPA1ACE2MMP2 | |
| SCHEMBL17323639 | 0.83 | MMP2 (0.55) | ALDH1A1THRBCYP2C9CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220211675-A1 | TIE-2 ACTIVATORS TARGETING THE SCHLEMM'S CANAL | EyePoint, Inc. | 2022-07-07 | — | — | US | disclosed |
| US-20180092883-A1 | PHOSPHATASE INHIBITORS FOR TREATING OCULAR DISEASES | EyePoint Pharmaceuticals, Inc. | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220211675-A1 | TIE-2 ACTIVATORS TARGETING THE SCHLEMM'S CANAL | TIE1, TEK, TGFB2 | ALDH1A1 3825/4885THRB 127/4885CYP2C9 4799/4885 |
| US-20180092883-A1 | PHOSPHATASE INHIBITORS FOR TREATING OCULAR DISEASES | PPM1G, PPM1F, PPM1A | ALDH1A1 3127/4885THRB 815/4885CYP2C9 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.