Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004494 | 0.93 | MAPK1 (0.52) | MAPK1LMNAPKMHTTMEN1 | |
| SCHEMBL2006414 | 0.93 | MAPK1 (0.51) | MAPK1LMNAPKMHTTMEN1 | |
| SCHEMBL2003580 | 0.91 | MAPT (0.44) | MAPK1LMNAPKMMEN1KMT2A | |
| SCHEMBL2005079 | 0.91 | MAPK1 (0.49) | MAPK1LMNAPKMMEN1KMT2A | |
| SCHEMBL2002436 | 0.90 | LMNA (0.55) | MAPK1LMNAPKMHTTMEN1 | |
| SCHEMBL2007585 | 0.90 | LMNA (0.49) | MAPK1LMNAPKMMEN1KMT2A | |
| SCHEMBL2003845 | 0.89 | RAB9A (0.45) | MAPK1LMNAHTTMEN1KMT2A | |
| SCHEMBL2005841 | 0.89 | MAPK1 (0.47) | MAPK1LMNAPKMMEN1KMT2A | |
| SCHEMBL2006431 | 0.88 | MAPK1 (0.50) | MAPK1LMNAPKMHTTMEN1 | |
| SCHEMBL2012543 | 0.87 | LMNA (0.39) | MAPK1LMNAPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |