Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2004278 | 0.93 | MAPT (0.45) | MAPTTSHRMEN1CYP3A4ALOX15 | |
| SCHEMBL2005819 | 0.92 | MEN1 (0.43) | MAPTTSHRMEN1KMT2AHSD17B10 | |
| SCHEMBL2005023 | 0.92 | LMNA (0.45) | MAPTTSHRMEN1CYP3A4ALOX15 | |
| SCHEMBL2002340 | 0.91 | MAPK1 (0.55) | MAPTTSHRMEN1CYP3A4ALOX15 | |
| SCHEMBL2002896 | 0.91 | PLA2G2A (0.49) | MAPTTSHRMEN1CYP3A4KMT2A | |
| SCHEMBL2003845 | 0.90 | RAB9A (0.45) | MAPTTSHRMEN1CYP3A4ALOX15 | |
| SCHEMBL2003641 | 0.89 | LMNA (0.41) | MAPTTSHRMEN1CYP3A4ALOX12 | |
| SCHEMBL2003946 | 0.88 | ALOX5AP (0.42) | MAPTTSHRMEN1CYP3A4KMT2A | |
| SCHEMBL2002364 | 0.88 | MAPT (0.41) | MAPTTSHRMEN1CYP3A4ALOX15 | |
| SCHEMBL2009777 | 0.87 | FAAH (0.41) | MAPTTSHRMEN1CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |