Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003946 | 0.92 | ALOX5AP (0.42) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2005079 | 0.92 | MAPK1 (0.49) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2010014 | 0.90 | MAPK1 (0.42) | MAPK1LMNAKMT2AALDH1A1CYP1A2 | |
| SCHEMBL2005116 | 0.90 | LMNA (0.42) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2007666 | 0.90 | MAPK1 (0.43) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2008598 | 0.90 | ALOX5AP (0.40) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2002340 | 0.89 | MAPK1 (0.55) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2003159 | 0.88 | ALOX5AP (0.46) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2006414 | 0.87 | MAPK1 (0.51) | MAPK1LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL2008229 | 0.87 | ALOX5AP (0.40) | MAPK1LMNAKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |