Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TARBP2 | Q15633 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22897082 | 0.88 | ALDH1A1 (0.44) | NPC1RAB9AHSD17B10MAPTALDH1A1 | |
| SCHEMBL20028437 | 0.87 | NPC1 (0.37) | TARBP2NPC1RAB9AHSD17B10MAPT | |
| SCHEMBL1739352 | 0.83 | ALDH1A1 (0.55) | TARBP2NPC1RAB9AGABRA2GABRB2 | |
| SCHEMBL22897239 | 0.82 | MAPK1 (0.52) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL24537117 | 0.82 | ALDH1A1 (0.40) | TARBP2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL15726277 | 0.80 | NPC1 (0.37) | TARBP2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL26964472 | 0.80 | ADORA3 (0.41) | NPC1RAB9AHSD17B10MAPTALDH1A1 | |
| SCHEMBL16559309 | 0.79 | ALDH1A1 (0.40) | TARBP2NPC1RAB9AHSD17B10MAPT | |
| SCHEMBL19330006 | 0.78 | DGAT1 (0.45) | NPC1RAB9AGABRA2GABRB2HSD17B10 | |
| SCHEMBL824832 | 0.78 | NPC1 (0.36) | TARBP2NPC1RAB9AGABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |