Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24537117 | 0.85 | ALDH1A1 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL26964472 | 0.82 | ADORA3 (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL15726277 | 0.82 | NPC1 (0.37) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL16559309 | 0.81 | ALDH1A1 (0.40) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL16559313 | 0.81 | NPC1 (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL26964483 | 0.79 | ALDH1A1 (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL16561934 | 0.78 | ALDH1A1 (0.36) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL20028441 | 0.78 | TARBP2 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL262959 | 0.77 | TSHR (0.38) | NPC1RAB9AALDH1A1NPSR1KDM4E | |
| SCHEMBL20028126 | 0.76 | CA12 (0.39) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143425-B2 | Heterocyclic aromatic compounds useful as growth hormone secretagogues | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |