Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12290084 | 0.76 | ALOX15 (0.64) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL1078509 | 0.74 | TP53 (0.58) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL20028539 | 0.74 | ALDH1A1 (0.57) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL2028506 | 0.74 | KMT2A (0.44) | MAPTALDH1A1GAAKMT2AHPGD | |
| SCHEMBL2681081 | 0.73 | GABRA2 (0.58) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL4318706 | 0.72 | KDM4E (0.54) | MAPTALDH1A1GAATP53MEN1 | |
| SCHEMBL22920713 | 0.71 | PDE4D (0.58) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL27769609 | 0.71 | ALDH1A1 (0.66) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL20028763 | 0.71 | GABRA2 (0.59) | MAPTALDH1A1GAATP53ALOX12 | |
| SCHEMBL15005226 | 0.71 | MAPT (1.00) | MAPTALDH1A1GAATP53ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |