Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 3/20 | 0.43 |
| ▸ | DCAF1 | Q9Y4B6 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 4/20 | 0.38 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PRKX | P51817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22885979 | 0.90 | PYGL (0.46) | PYGLDCAF1MEN1KMT2APOLB | |
| SCHEMBL20027914 | 0.86 | DCAF1 (0.48) | PYGLDCAF1MEN1KMT2A | |
| SCHEMBL21854245 | 0.84 | CAPN1 (0.51) | DCAF1 | |
| SCHEMBL20027555 | 0.84 | CAPN1 (0.51) | DCAF1 | |
| SCHEMBL20028717 | 0.83 | DCAF1 (0.50) | PYGLDCAF1KMT2ACNR1CNR2 | |
| SCHEMBL20028599 | 0.82 | ROCK2 (0.53) | DCAF1MEN1KMT2APOLBCTSA | |
| SCHEMBL22885966 | 0.82 | CTSV (0.48) | PYGLDCAF1CNR1CNR2CTSL | |
| SCHEMBL22885920 | 0.82 | PYGL (0.40) | PYGLDCAF1CNR1CNR2CCR1 | |
| SCHEMBL22886842 | 0.82 | DCAF1 (0.39) | PYGLDCAF1CNR1CNR2CTSL | |
| SCHEMBL22886578 | 0.82 | IDO1 (0.44) | PYGLDCAF1CNR1CNR2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |