Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11810834 | 0.85 | SMN1; SMN2 (0.44) | KDM4ELMNATP53PIN1CYP1A2 | |
| SCHEMBL27873777 | 0.85 | IKBKB (0.46) | KDM4ETP53CYP1A2MAPK1CASP1 | |
| SCHEMBL23294365 | 0.84 | ALDH1A1 (0.40) | TP53CYP1A2MAPK1CYP2C19ALDH1A1 | |
| SCHEMBL28852253 | 0.84 | ALDH1A1 (0.49) | LMNATP53ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL30357667 | 0.83 | MKNK1 (0.49) | KDM4ELMNATP53CYP1A2ALDH1A1 | |
| SCHEMBL11400972 | 0.81 | AKT1 (0.43) | KDM4ELMNATP53PIN1CYP1A2 | |
| SCHEMBL15947001 | 0.80 | HAO1 (0.39) | PIN1CASP1 | |
| SCHEMBL1834558 | 0.78 | PIN1 (0.53) | KDM4ELMNATP53PIN1CYP1A2 | |
| SCHEMBL1290355 | 0.78 | HPGD (0.41) | KDM4ELMNAPIN1ALDH1A1MAPT | |
| SCHEMBL703836 | 0.77 | PIN1 (0.52) | PIN1CYP1A2CYP2C19ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | claimed |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| CN-107325284-B | Hyperbranched polyphenyl triazole formate as well as preparation method and application thereof | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KDM4E 3495/4885LMNA 1415/4885TP53 1804/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | KDM4E 3117/4885LMNA 1105/4885TP53 1368/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | KDM4E 3495/4885LMNA 1415/4885TP53 1804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.