Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | TPMT | P51580 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 10/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22395360 | 0.82 | GAA (0.43) | LMNAGAANPC1RAB9AALOX15 | |
| SCHEMBL23196210 | 0.81 | ALDH1A1 (0.51) | LMNAGAANPC1RAB9AALOX15 | |
| SCHEMBL20554157 | 0.81 | NR1H4 (0.39) | LMNAGAATPMTNR1H4CYP3A4 | |
| SCHEMBL17851275 | 0.81 | NPC1 (0.51) | LMNAGAANPC1RAB9ATPMT | |
| SCHEMBL22672582 | 0.77 | LMNA (0.37) | LMNAGAANPC1RAB9AALOX15 | |
| SCHEMBL21264224 | 0.77 | GAA (0.48) | LMNAGAANPC1RAB9AMAPT | |
| SCHEMBL20031235 | 0.77 | RAB9A (0.41) | LMNAGAANPC1RAB9AMAPT | |
| SCHEMBL19900506 | 0.71 | RARB (0.44) | MAPTMEN1ALDH1A1KMT2AKDM4E | |
| SCHEMBL20944436 | 0.70 | RAB9A (0.51) | LMNANPC1RAB9AALOX15TSHR | |
| SCHEMBL20031544 | 0.69 | NR1H4 (0.48) | NPC1RAB9AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018059314-A1 | AZABICYCLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2018-04-05 | — | — | WO | disclosed |