Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 16/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20031544 | 1.00 | NR1H4 (0.48) | NR1H4MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL20031251 | 0.83 | NR1H4 (0.45) | NR1H4MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL26047391 | 0.81 | NR1H4 (0.48) | NR1H4MAPT | |
| SCHEMBL26045428 | 0.76 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL19123541 | 0.73 | SMN1; SMN2 (0.70) | NR1H4MAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL22395360 | 0.70 | GAA (0.43) | MAPTSMN1; SMN2RAB9ANPC1ALDH1A1 | |
| SCHEMBL20859151 | 0.70 | NR1H4 (0.36) | NR1H4RAB9ANPC1 | |
| SCHEMBL23731075 | 0.69 | NR1H4 (0.58) | NR1H4 | |
| SCHEMBL20554157 | 0.69 | NR1H4 (0.39) | NR1H4CYP3A4CYP2C8 | |
| SCHEMBL20031347 | 0.69 | LMNA (0.39) | NR1H4MAPTSMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018059314-A1 | AZABICYCLE DERIVATIVES AND PREPARATION METHOD AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2018-04-05 | — | — | WO | disclosed |