Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 18/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20859145 | 0.79 | NR1H4 (0.36) | NR1H4NPC1RAB9A | |
| SCHEMBL20031544 | 0.70 | NR1H4 (0.48) | NR1H4NPC1RAB9A | |
| SCHEMBL20031474 | 0.70 | NR1H4 (0.48) | NR1H4NPC1RAB9A | |
| SCHEMBL23196210 | 0.68 | ALDH1A1 (0.51) | NPC1RAB9A | |
| SCHEMBL17851275 | 0.68 | NPC1 (0.51) | NR1H4NPC1RAB9A | |
| SCHEMBL22395360 | 0.67 | GAA (0.43) | NPC1RAB9A | |
| SCHEMBL20554157 | 0.66 | NR1H4 (0.39) | NR1H4 | |
| SCHEMBL20031347 | 0.66 | LMNA (0.39) | NR1H4NPC1RAB9A | |
| SCHEMBL26047391 | 0.65 | NR1H4 (0.48) | NR1H4 | |
| SCHEMBL20031235 | 0.65 | RAB9A (0.41) | NR1H4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233850-B1 | HYDROXY CONTAINING FXR (NR1H4) MODULATING COMPOUNDS | GILEAD SCIENCES INC (US) | 2019-04-03 | — | — | EP | disclosed |