SCHEMBL20031910

SCHEMBL20031910

CCOc1ccc2c(c1)CCc1c(C#N)c(C#N)c3c(c1-2)-c1ccc(OCC)cc1CC3

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 5/20 0.44
CYP19A1 P11511 2/20 0.42
CYP11B1 P15538 2/20 0.42
CYP11B2 P19099 2/20 0.42
MAPK1 P28482 2/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39
GLA P06280 1/20 0.39
MAOB P27338 3/20 0.38
MAOA P21397 2/20 0.38
KDM4E B2RXH2 2/20 0.38
ALDH1A1 P00352 2/20 0.38
ESR1 P03372 1/20 0.38
LMNA P02545 1/20 0.38
ALOX12 P18054 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
HPGD P15428 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20031875 0.95 EGFR (0.51) EGFRCYP19A1CYP11B1CYP11B2MAPK1
SCHEMBL22702989 0.86 THRA (0.47) EGFRMAOBKDM4EALDH1A1HPGD
SCHEMBL20031646 0.84 EGFR (0.58) EGFRCYP19A1CYP11B2MAPK1GLA
SCHEMBL20031909 0.82 MAOB (0.43) EGFRMAPK1MAOBMAOA
SCHEMBL25017016 0.82 BRD4 (0.57) EGFRMAPK1MAOBKDM4EALDH1A1
SCHEMBL22703046 0.81 EGFR (0.44) EGFRMAPK1GLAMAOBMAOA
SCHEMBL22683261 0.80 MEN1 (0.46) EGFRMAOBALDH1A1MAPTL3MBTL1
SCHEMBL22683256 0.80 BRD4 (0.53) EGFRMAOBMAOAKDM4EMAPT
SCHEMBL20031900 0.78 EGFR (0.53) EGFRMAPK1GLAKDM4EALDH1A1
SCHEMBL20031911 0.78 MAOB (0.41) EGFRMAPK1MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018063105-A1 [5]HELICENE DERIVATIVES AS MOLECULAR REPORTERS FOR DIAGNOSTIC APPLICATIONS AND METHODS OF SYNTHESIS THEREFOR NATIONAL SCIENCE AND TECHNOLOGY DEVELOPMENT AGENCY (TH) 2018-04-05 WO disclosed